A importância dos receptores

Saiu um livro sobre Toxicologia Molecular da coleção Experientia Supplementum, onde há um capítulo que trata da importância dos receptores como mediadores da toxicidade e da interferência hormonal, escrito por um grupo de pesquisadores do Instituto Karolinska de Estocolmo. Outros capítulos no livro também são bastante interessantes.
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Segue o abstract do capítulo:

Many toxic compounds exert their harmful effects by activating of certain receptors, which in turn leads to dysregulation of transcription. Some of these receptors are so called xenosensors. They are activated by external chemicals and evoke a cascade of events that lead to the elimination of the chemical from the system. Other receptors that are modulated by toxic substances are hormone receptors, particularly the ones of the nuclear receptor family. Some environmental chemicals resemble endogenous hormones and can falsely activate these receptors, leading to undesired activity in the cell. Furthermore, excessive activation of the xenosensors can lead to disturbances of the integrity of the system as well. In this chapter, the concepts of receptor-mediated toxicity and hormone disruption are introduced. We start by describing environmental chemicals that can bind to xenosensors and nuclear hormone receptors. We then describe the receptors most commonly targeted by environmental chemicals. Finally, the mechanisms by which receptor-mediated events can disrupt the system are depicted.

Rüegg J, Penttinen-Damdimopoulou P, Mäkelä S, Pongratz I, Gustafsson JA.
Receptors mediating toxicity and their involvement in endocrine disruption.
in sit
Molecular, Clinical and Environmental Toxicology
Volume 1: Molecular Toxicology
Series: Experientia Supplementum , Vol. 99:289-323
http://www.springer.com/birkhauser/biosciences/book/978-3-7643-8335-0